Description

Long[R3] insulin-like growth factor-I (IGF-1 Long[R3] ) is a

Human Recombinant, single, non-glycosylated, polypeptide

chain containing 83 amino acids. It is an analog of human

IGF-1 comprising the complete human IGF-1 sequence

with the substitution of an Arginine (Arg or R) for the

Glutamic Acid (Glu or E) at position 3 (hence R3), and a 13

amino acid extension peptide at the N-terminus.

This analog has been engineered with the express purpose

of increasing biological activity. IGF-1 Long[R3] is

significantly more potent than IGF-1 in vitro and in vivo. The

enhanced potency is due to the markedly decreased

binding of IGF-1 Long[R3] to all IGF binding proteins.

These binding proteins normally inhibit the biological

actions of IGFs.

IGF-1 stands for insulin-like growth factor. It is a natural

substance that is produced in the human body and is at its

highest natural levels during puberty. During puberty IGF-1

is the most responsible for the natural muscle growth that

occurs during these few years. There are many different

things that IGF-1 does in the human body

Among the effects the most positive are:

. increased amino acid transport to cells

. increased glucose transport

. increased protein synthesis

. decreased protein degradation